X-ray diffraction
1.59Å resolution

Crystal structure of M. tuberculosis phosphopantetheinyl transferase PptT


Function and Biology Details

Reaction catalysed:
CoA-(4'-phosphopantetheine) + an apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + an [acyl-carrier-protein]
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
4'-phosphopantetheinyl transferase PptT Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 26 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
  • Canonical: O33336 (Residues: 1-227; Coverage: 100%)
Gene names: Rv2794c, pptT
Sequence domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2221
Unit cell:
a: 99.86Å b: 121.505Å c: 48.78Å
α: 90° β: 90° γ: 90°
R R work R free
0.171 0.17 0.204
Expression system: Escherichia coli