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protein domain complex with ssDNA

X-ray diffraction
2.545Å resolution
PDB entry 4qgu coloured by chain, front view.
PDB entry 4qgu coloured by chain, side view.
PDB entry 4qgu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Gamma-interferon-inducible protein 16 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 23914.18 Å2
Buried surface area: 2959.99 Å2
Dissociation area: 1,480 Å2
Dissociation energy (ΔGdiss): -12.95 kcal/mol
Dissociation entropy (TΔSdiss): 32.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118016

Macromolecules

Gamma-interferon-inducible protein 16
Chains: A, B
Length: 206 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16666 (Residues: 192-393; Coverage: 26%)
Gene names: IFI16, IFNGIP1
Pfam: HIN-200/IF120x domain
InterPro:
CATH: Nucleic acid-binding proteins
Gamma-interferon-inducible protein 16 in PDB entry 4qgu, assembly 1, front view.
Gamma-interferon-inducible protein 16 in PDB entry 4qgu, assembly 1, side view.
Gamma-interferon-inducible protein 16 in PDB entry 4qgu, assembly 1, top view.
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DNA chains C, D
Name: DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3')
Representative chains: C, D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.73 KDa
DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3') in PDB entry 4qgu, assembly 1, front view.
DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3') in PDB entry 4qgu, assembly 1, side view.
DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3') in PDB entry 4qgu, assembly 1, top view.
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