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Two distinct conformational states of GlyRS captured in crystal lattice

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: glycyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.14: Glycine--tRNA ligase

Reaction catalysed:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Systematic name:
Glycine:tRNA(Gly) ligase (AMP-forming)
Alternative Name(s):
  • Glycyl translase
  • Glycyl-tRNA synthetase
  • Glycyl-transfer RNA synthetase
  • Glycyl-transfer ribonucleate synthetase
  • Glycyl-transfer ribonucleic acid synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03129
Domain description: Anticodon binding domain
Occurring in:
  1. Glycine--tRNA ligase
The deposited structure of PDB entry 4qei contains 1 copy of Pfam domain PF03129 (Anticodon binding domain) in Glycine--tRNA ligase. Showing 1 copy in chain A.

PF00587
Domain description: tRNA synthetase class II core domain (G, H, P, S and T)
Occurring in:
  1. Glycine--tRNA ligase
The deposited structure of PDB entry 4qei contains 1 copy of Pfam domain PF00587 (tRNA synthetase class II core domain (G, H, P, S and T)) in Glycine--tRNA ligase. Showing 1 copy in chain A.

Rfam RNA family (Rfam)
RF00005
Domain description: tRNA
Occurring in:
  1. tRNA-Gly-CCC-2-2
The deposited structure of PDB entry 4qei contains 1 copy of Rfam domain RF00005 (tRNA) in tRNA-Gly-CCC-2-2. Showing 1 copy in chain B [auth C].

InterPro InterPro annotations
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. Glycine--tRNA ligase
IPR004154
Domain description: Anticodon-binding
Occurring in:
  1. Glycine--tRNA ligase
IPR036621
Domain description: Anticodon-binding domain superfamily
Occurring in:
  1. Glycine--tRNA ligase
IPR002314
Domain description: Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Occurring in:
  1. Glycine--tRNA ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. Glycine--tRNA ligase
IPR033731
Domain description: Glycyl-tRNA synthetase-like core domain
Occurring in:
  1. Glycine--tRNA ligase
IPR002315
Domain description: Glycyl-tRNA synthetase
Occurring in:
  1. Glycine--tRNA ligase
IPR027031
Domain description: Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
Occurring in:
  1. Glycine--tRNA ligase

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