4qeb

X-ray diffraction
3.21Å resolution

Dcps in complex with covalent inhibitor targeting Tyrosine

Released:
Source organism: Homo sapiens
Entry author: Liu S

Function and Biology Details

Reaction catalysed:
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
m7GpppX diphosphatase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 337 amino acids
Theoretical weight: 38.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96C86 (Residues: 2-337; Coverage: 100%)
Gene names: DCPS, DCS1, HINT5, HSPC015
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 101.25Å b: 105.23Å c: 139.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.211 0.276
Expression system: Escherichia coli BL21(DE3)