PDBe 4q9z

X-ray diffraction
2.6Å resolution

Human Protein Kinase C Theta in Complex with Compound35 ((1R)-9-(AZETIDIN-3-YLAMINO)-1,8-DIMETHYL-3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C theta type Chains: A, B
Molecule details ›
Chains: A, B
Length: 334 amino acids
Theoretical weight: 39.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04759 (Residues: 374-706; Coverage: 47%)
Gene names: PRKCQ, PRKCT
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 76.954Å b: 78.575Å c: 146.966Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.219 0.256
Expression system: Spodoptera frugiperda