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P-glycoprotein cocrystallised with QZ-Val

Source organism: Mus musculus
Biochemical function: ABC-type transporter activity
Biological process: positive regulation of response to drug
Cellular component: intercellular canaliculus

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EC 7.6.2.2: ABC-type xenobiotic transporter

Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
  • ATP phosphohydrolase (steroid-exporting)
  • MDR protein
  • Multidrug-resistance protein
  • P-glycoprotein
  • PDR protein
  • Pleiotropic-drug-resistance protein
  • Steroid-transporting ATPase
  • Xenobiotic-transporting ATPase

EC 7.6.2.1: P-type phospholipid transporter

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
  • Aminophospholipid-transporting ATPase
  • Flippase
  • Phospholipid-transporting ATPase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. ATP-dependent translocase ABCB1
The deposited structure of PDB entry 4q9j contains 2 copies of Pfam domain PF00005 (ABC transporter) in ATP-dependent translocase ABCB1. Showing 2 copies in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. ATP-dependent translocase ABCB1
The deposited structure of PDB entry 4q9j contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in ATP-dependent translocase ABCB1. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR039421
Domain description: Type 1 protein exporter
Occurring in:
  1. ATP-dependent translocase ABCB1

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. ATP-dependent translocase ABCB1
The deposited structure of PDB entry 4q9j contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in ATP-dependent translocase ABCB1. Showing 2 copies in chain A.
1.20.1560.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: ABC transporter transmembrane region fold
Homology: ABC transporter type 1, transmembrane domain
Occurring in:
  1. ATP-dependent translocase ABCB1
The deposited structure of PDB entry 4q9j contains 1 copy of CATH domain 1.20.1560.10 (ABC transporter transmembrane region fold) in ATP-dependent translocase ABCB1. Showing 1 copy in chain A.

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