PDBe 4q7h

X-ray diffraction
2.59Å resolution

Crystal structure of SAMHD1 catalytic core with GTP

Released:
Source organism: Homo sapiens
Entry authors: Xiaohong Q, Yanhong L, Jia K, Xiaofang Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 526 amino acids
Theoretical weight: 61.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 109-626; Coverage: 83%)
Gene names: MOP5, SAMHD1
Sequence domains: HD domain
Structure domains: Hypothetical protein af1432

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P212121
Unit cell:
a: 80.943Å b: 142.765Å c: 199.501Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.248
Expression system: Escherichia coli