4q3s

X-ray diffraction
2.11Å resolution

Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE

Released:

Function and Biology Details

Reaction catalysed:
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 385 amino acids
Theoretical weight: 42.27 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6WVP6 (Residues: 1-364; Coverage: 100%)
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P213
Unit cell:
a: 178.212Å b: 178.212Å c: 178.212Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.206
Expression system: Escherichia coli BL21(DE3)