› 4pyp

X-ray diffraction
3.17Å resolution

Crystal structure of the human glucose transporter GLUT1

Released:
DOI: 10.2210/pdb4pyp/pdb
PDB 4pyp coloured by chain and viewed from the front.
PDB 4pyp coloured by chain and viewed from the side.
PDB 4pyp coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Deng D, Yan CY, Xu C, Wu JP, Sun PC, Hu MX, Yan N

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 2, facilitated glucose transporter member 1 Chain: A
Molecule details ›
Chain: A
Length: 504 amino acids
Theoretical weight: 55.74 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P11166 (Residues: 1-492; Coverage: 100%)
Gene names: GLUT1, SLC2A1
Sequence domains: Sugar (and other) transporter
Structure domains: MFS general substrate transporter like domains

Ligands and Environments

1 bound ligand:
Ligand BNG 1 x BNG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 120.509Å b: 101.996Å c: 65.604Å
α: 90° β: 101.27° γ: 90°
R-values:
R R work R free
0.234 0.232 0.278
Expression system: Trichoplusia ni

Quick links

Citations

75 review citations

The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.
Hou et al. (2022)
74 more

44 mentions without citation

Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses.
Di Dedda et al. (2019)
43 more