› 4pwj

X-ray diffraction
1.55Å resolution

Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid

Released:
DOI: 10.2210/pdb4pwj/pdb
PDB 4pwj coloured by chain and viewed from the front.
PDB 4pwj coloured by chain and viewed from the side.
PDB 4pwj coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin.
Yokoyama T, Kosaka Y, Mizuguchi M
J. Med. Chem. 57 8928-35 (2014)
PMID: 25314129

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 1-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 30Z 2 x 30Z
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21212
Unit cell:
a: 43.565Å b: 85.391Å c: 64.221Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.219
Expression system: Escherichia coli

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Citations

2 review citations

Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis.
Ferreira et al. (2019)
1 more