Structure analysis

Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate

X-ray diffraction
2Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero octamer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 11900 Å2
Buried surface area: 1400 Å2
Dissociation area: 600 Å2
Dissociation energy (ΔGdiss): 4 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -18 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero octamer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B
Length: 235 amino acids
Theoretical weight: 26.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DMV8 (Residues: 386-613; Coverage: 36%)
Gene names: HSP72, HSPA1, HSPA1A, HSX70
InterPro:
CATH:

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Chains: C, D
Length: 7 amino acids
Theoretical weight: 787 Da
Source organism: Homo sapiens
Expression system: Not provided

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