EC 1.1.1.27: L-lactate dehydrogenase
Reaction catalysed:
(S)-lactate + NAD(+) = pyruvate + NADH
Systematic name:
(S)-lactate:NAD(+) oxidoreductase
Alternative Name(s):
- L(+)-nLDH
- L-(+)-lactate dehydrogenase
- L-lactic acid dehydrogenase
- L-lactic dehydrogenase
- Lactate dehydrogenase
- Lactate dehydrogenase NAD-dependent
- Lactic acid dehydrogenase
- Lactic dehydrogenase
- NAD-lactate dehydrogenase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 4ply contains 8 copies of Pfam domain PF02866 (lactate/malate dehydrogenase, alpha/beta C-terminal domain) in L-lactate dehydrogenase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4ply_1_A_Pfam_PF02866_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4ply</span> contains 8 copies of Pfam domain <span class='highlight'>PF02866 (lactate/malate dehydrogenase, alpha/beta C-terminal domain)</span> in <span class='highlight'>L-lactate dehydrogenase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 4ply contains 8 copies of Pfam domain PF00056 (lactate/malate dehydrogenase, NAD binding domain) in L-lactate dehydrogenase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4ply_1_A_Pfam_PF00056_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4ply</span> contains 8 copies of Pfam domain <span class='highlight'>PF00056 (lactate/malate dehydrogenase, NAD binding domain)</span> in <span class='highlight'>L-lactate dehydrogenase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotations
Structure domains
CATH domains
3.90.110.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homology:
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Occurring in:
![The deposited structure of PDB entry 4ply contains 8 copies of CATH domain 3.90.110.10 (L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2) in L-lactate dehydrogenase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4ply_1_A_CATH_3.90.110.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4ply</span> contains 8 copies of CATH domain <span class='highlight'>3.90.110.10 (L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2)</span> in <span class='highlight'>L-lactate dehydrogenase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 4ply contains 8 copies of CATH domain 3.40.50.720 (Rossmann fold) in L-lactate dehydrogenase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4ply_1_A_CATH_3.40.50.720_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4ply</span> contains 8 copies of CATH domain <span class='highlight'>3.40.50.720 (Rossmann fold)</span> in <span class='highlight'>L-lactate dehydrogenase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")