› 4pjm

X-ray diffraction
2.05Å resolution

Myosin VI motor domain in the Pi release state, space group P212121 - soaked with PO4 - located in the active site

Released:
DOI: 10.2210/pdb4pjm/pdb
PDB 4pjm coloured by chain and viewed from the front.
PDB 4pjm coloured by chain and viewed from the side.
PDB 4pjm coloured by chain and viewed from the top.
Source organism: Sus scrofa
Entry authors: Isabet T, Benisty H, Llinas P, Sweeney HL, Houdusse A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-VI Chain: A
Molecule details ›
Chain: A
Length: 788 amino acids
Theoretical weight: 89.85 KDa
Source organism: Sus scrofa
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: F1RQI7 (Residues: 2-789; Coverage: 62%)
Gene name: MYO6
Sequence domains: Myosin head (motor domain)
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand PO4 1 x PO4
Ligand MG 1 x MG
Ligand ADP 1 x ADP
Ligand GOL 7 x GOL
Ligand IPA 2 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 91.49Å b: 95.33Å c: 103.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.196
Expression system: Spodoptera frugiperda

Quick links

Citations

15 review citations

Cardiac myosin contraction and mechanotransduction in health and disease.
Barrick et al. (2021)
14 more