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Crystal structure of human adenovirus 2 protease a substrate based nitrile inhibitor

Source organism: Human adenovirus 2
Biochemical function: hydrolase activity
Biological process: proteolysis
Cellular component: virion component

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EC 3.4.22.39: Adenain

Reaction catalysed:
Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid).

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00770
Domain description: Adenovirus endoprotease
Occurring in:
  1. Protease
The deposited structure of PDB entry 4pie contains 1 copy of Pfam domain PF00770 (Adenovirus endoprotease) in Protease. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000855
Domain description: Peptidase C5, adenain
Occurring in:
  1. Protease
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Protease

Structure domain

CATH CATH domain
3.40.395.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Adenoviral Proteinase; Chain
Homology: Adenoviral Proteinase; Chain A
Occurring in:
  1. Protease
The deposited structure of PDB entry 4pie contains 1 copy of CATH domain 3.40.395.10 (Adenoviral Proteinase; Chain) in Protease. Showing 1 copy in chain A.

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