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Crystal structure of S. aureus Homoserine Dehydrogenase at pH8.5

X-ray diffraction
2.2Å resolution
PDB entry 4pg8 coloured by chain, front view.
PDB entry 4pg8 coloured by chain, side view.
PDB entry 4pg8 coloured by chain, top view.
Source organism: Staphylococcus aureus M1064
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Homoserine dehydrogenase
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Multimeric state: homo dimer
Accessible surface area: 35682.8 Å2
Buried surface area: 6203.84 Å2
Dissociation area: 1,156.53 Å2
Dissociation energy (ΔGdiss): 0.68 kcal/mol
Dissociation entropy (TΔSdiss): 14.38 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-102390

Macromolecules

Homoserine dehydrogenase
Chains: A, B
Length: 468 amino acids
Theoretical weight: 51.38 KDa
Source organism: Staphylococcus aureus M1064
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0M3KKV6 (Residues: 1-426; Coverage: 95%)
Gene name: U5K_01898
Pfam:
InterPro:
CATH:
Homoserine dehydrogenase in PDB entry 4pg8, assembly 1, front view.
Homoserine dehydrogenase in PDB entry 4pg8, assembly 1, side view.
Homoserine dehydrogenase in PDB entry 4pg8, assembly 1, top view.
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