PDBe 4pcw

X-ray diffraction
2.2Å resolution

Crystal Structure of the N-terminal Domain of Human Profilaggrin at 2.2 A Resolution


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Filaggrin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 94 amino acids
Theoretical weight: 11.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P20930 (Residues: 1-92; Coverage: 2%)
Gene name: FLG
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 40.492Å b: 85.285Å c: 96.901Å
α: 90° β: 90° γ: 90°
R R work R free
0.198 0.196 0.242
Expression system: Escherichia coli