4pbx

X-ray diffraction
3.15Å resolution

Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma

Released:
Source organism: Homo sapiens
Entry authors: Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase S Chain: A
Molecule details ›
Chain: A
Length: 584 amino acids
Theoretical weight: 64.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13332 (Residues: 30-614; Coverage: 30%)
  • Best match: Q13332-6 (Residues: 30-601)
Gene name: PTPRS
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P6122
Unit cell:
a: 198.78Å b: 198.78Å c: 132.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.265
Expression system: Homo sapiens