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Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with NDSB-201

X-ray diffraction
1.502Å resolution
PDB entry 4p7u coloured by chain, front view.
PDB entry 4p7u coloured by chain, side view.
PDB entry 4p7u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TGF-beta receptor type-2
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Multimeric state: monomeric
Accessible surface area: 5884.54 Å2
Buried surface area: 373.35 Å2
Dissociation area: 186.68 Å2
Dissociation energy (ΔGdiss): -8.75 kcal/mol
Dissociation entropy (TΔSdiss): 2.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153364

Macromolecules

TGF-beta receptor type-2
Chain: A
Length: 112 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37173 (Residues: 50-159; Coverage: 20%)
Gene name: TGFBR2
Pfam: Transforming growth factor beta receptor 2 ectodomain
InterPro:
CATH: CD59
TGF-beta receptor type-2 in PDB entry 4p7u, assembly 1, front view.
TGF-beta receptor type-2 in PDB entry 4p7u, assembly 1, side view.
TGF-beta receptor type-2 in PDB entry 4p7u, assembly 1, top view.
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