X-ray diffraction
1.5Å resolution

Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with NDSB-201

Source organism: Homo sapiens
Entry authors: Wangkanont K, Forest KT

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
TGF-beta receptor type-2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P37173 (Residues: 50-159; Coverage: 20%)
Gene name: TGFBR2
Sequence domains: Transforming growth factor beta receptor 2 ectodomain
Structure domains: CD59

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 33.574Å b: 40.463Å c: 75.837Å
α: 90° β: 90° γ: 90°
R R work R free
0.174 0.17 0.206
Expression system: Escherichia coli BL21(DE3)