X-ray diffraction
2.3Å resolution

Crystal Structure of human MLH1

Source organism: Homo sapiens
Primary publication:
Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Acta Crystallogr F Struct Biol Commun 71 981-5 (2015)
PMID: 26249686

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA mismatch repair protein Mlh1 Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 38.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P40692 (Residues: 1-347; Coverage: 46%)
Gene names: COCA2, MLH1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P64
Unit cell:
a: 94.568Å b: 94.568Å c: 85.825Å
α: 90° β: 90° γ: 120°
R R work R free
0.205 0.203 0.254
Expression system: Escherichia coli BL21(DE3)