X-ray diffraction
1.58Å resolution

Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor.


Function and Biology Details

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cathepsin S Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 226 amino acids
Theoretical weight: 25.14 KDa
Source organism: Homo sapiens
Expression system: Enterobacteria phage L1
  • Canonical: P25774 (Residues: 114-331; Coverage: 69%)
Gene name: CTSS
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P1
Unit cell:
a: 67.253Å b: 67.311Å c: 67.778Å
α: 100.9° β: 94.86° γ: 117.99°
R R work R free
0.198 0.198 0.222
Expression system: Enterobacteria phage L1