4p6e

X-ray diffraction
1.8Å resolution

Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Wang Y, Jadhav PK, Deng GG

Function and Biology Details

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin S Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.65 KDa
Source organism: Homo sapiens
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: P25774 (Residues: 109-331; Coverage: 71%)
Gene name: CTSS
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P4122
Unit cell:
a: 85.692Å b: 85.692Å c: 151.496Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.176 0.199
Expression system: Enterobacteria phage L1