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Structure of Clostridium perfringens Enterotoxin with a peptide derived from a modified version of ECL-2 of Claudin 2

X-ray diffraction
3.38Å resolution
PDB entry 4p5h coloured by chain, front view.
PDB entry 4p5h coloured by chain, side view.
PDB entry 4p5h coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Claudin-2 and Heat-labile enterotoxin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 38584.39 Å2
Buried surface area: 7578.12 Å2
Dissociation area: 1,160.8 Å2
Dissociation energy (ΔGdiss): 1.58 kcal/mol
Dissociation entropy (TΔSdiss): 20.01 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-131556
Assembly 2
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Assembly Name: Claudin-2 and Heat-labile enterotoxin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 38784.89 Å2
Buried surface area: 7667.44 Å2
Dissociation area: 1,127.14 Å2
Dissociation energy (ΔGdiss): -0.26 kcal/mol
Dissociation entropy (TΔSdiss): 20.03 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-131556
Assembly 3 (preferred)
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Assembly Name: Claudin-2 and Heat-labile enterotoxin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 38813.77 Å2
Buried surface area: 7343.72 Å2
Dissociation area: 1,149.94 Å2
Dissociation energy (ΔGdiss): 0.64 kcal/mol
Dissociation entropy (TΔSdiss): 20.02 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-131556
Assembly 4
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Assembly Name: Claudin-2 and Heat-labile enterotoxin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 39003.99 Å2
Buried surface area: 7482.83 Å2
Dissociation area: 1,140.97 Å2
Dissociation energy (ΔGdiss): 0.46 kcal/mol
Dissociation entropy (TΔSdiss): 20 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-131556
Assembly 5
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Assembly Name: Claudin-2 and Heat-labile enterotoxin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 38872.02 Å2
Buried surface area: 7600.69 Å2
Dissociation area: 1,147.48 Å2
Dissociation energy (ΔGdiss): 3.26 kcal/mol
Dissociation entropy (TΔSdiss): 20 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-131556

Macromolecules

Claudin-2
Chains: 1, 2, 3, 4, P, Q, R, S, T, U, V, W, X, Y, Z
Length: 20 amino acids
Theoretical weight: 2.38 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: O88552 (Residues: 141-160; Coverage: 9%)
Gene name: Cldn2
Claudin-2 in PDB entry 4p5h, assembly 3, front view.
Claudin-2 in PDB entry 4p5h, assembly 3, side view.
Claudin-2 in PDB entry 4p5h, assembly 3, top view.
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Heat-labile enterotoxin B chain
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Length: 286 amino acids
Theoretical weight: 31.52 KDa
Source organism: Clostridium perfringens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P01558 (Residues: 38-319; Coverage: 88%)
Gene name: cpe
Pfam: Clostridium enterotoxin
InterPro: Clostridium enterotoxin
CATH:
Heat-labile enterotoxin B chain in PDB entry 4p5h, assembly 3, front view.
Heat-labile enterotoxin B chain in PDB entry 4p5h, assembly 3, side view.
Heat-labile enterotoxin B chain in PDB entry 4p5h, assembly 3, top view.
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