PDBe 4p59

X-ray diffraction
3.4Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Receptor tyrosine-protein kinase erbB-3 Chain: A
Molecule details ›
Chain: A
Length: 627 amino acids
Theoretical weight: 69.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21860 (Residues: 20-640; Coverage: 47%)
Gene names: ERBB3, HER3
Sequence domains:
Structure domains:
MOR09825 Fab fragment heavy chain Chain: H
Molecule details ›
Chain: H
Length: 238 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
MOR09825 Fab fragment light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 124.226Å b: 140.939Å c: 180.247Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.25
Expression systems:
  • Homo sapiens
  • Escherichia coli