4p58

X-ray diffraction
2.06Å resolution

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catechol O-methyltransferase Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O88587 (Residues: 47-258; Coverage: 80%)
Gene names: Comt, Comt1
Sequence domains: O-methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: I4122
Unit cell:
a: 98.584Å b: 98.584Å c: 115.104Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.147 0.145 0.199
Expression system: Escherichia coli