› 4p3i

X-ray diffraction
1.69Å resolution

Structure of the P domain from a GI.7 Norovirus variant in complex with LeA HBGA.

Released:
DOI: 10.2210/pdb4p3i/pdb
PDB entry 4p3i coloured by chain, front view.
PDB entry 4p3i coloured by chain, side view.
PDB entry 4p3i coloured by chain, top view.
Source organism: Norovirus Hu/GI.7/TCH-060/USA/2003
Primary publication:
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Shanker S, Czako R, Sankaran B, Atmar RL, Estes MK, Prasad BV
J Virol 88 6168-80 (2014)
PMID: 24648450

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Major capsid protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 301 amino acids
Theoretical weight: 32.62 KDa
Source organism: Norovirus Hu/GI.7/TCH-060/USA/2003
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: G8FL04 (Residues: 226-526; Coverage: 56%)
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P1
Unit cell:
a: 62.168Å b: 63.277Å c: 90.4Å
α: 72.77° β: 82.2° γ: 60.31°
R-values:
R R work R free
0.156 0.155 0.177
Expression system: Escherichia coli BL21(DE3)

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Citations

13 review citations

Human noroviruses: recent advances in a 50-year history.
Atmar et al. (2018)
12 more

1 mention without citation

Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Shanker et al. (2014)