PDBe 4p3e

X-ray diffraction
3.5Å resolution

Structure of the human SRP S domain

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (3 distinct):
Signal recognition particle 19 kDa protein Chain: B
Molecule details ›
Chain: B
Length: 128 amino acids
Theoretical weight: 14.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09132 (Residues: 1-120; Coverage: 83%)
Gene name: SRP19
Sequence domains: SRP19 protein
Structure domains: Signal recognition particle, SRP19-like subunit
Signal recognition particle subunit SRP68 Chain: C
Molecule details ›
Chain: C
Length: 216 amino acids
Theoretical weight: 25.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHB9 (Residues: 47-254; Coverage: 33%)
Gene name: SRP68
Structure domains: Hyaluronidase domain-like
SRP RNA (124-mer) Chain: A
Molecule details ›
Chain: A
Length: 125 nucleotides
Theoretical weight: 40.55 KDa

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 125.649Å b: 70.53Å c: 106.493Å
α: 90° β: 100.46° γ: 90°
R-values:
R R work R free
0.246 0.244 0.285
Expression system: Escherichia coli