X-ray diffraction
2.4Å resolution

Swapped Dimer of Mycobacterial Adenylyl cyclase Rv1625c: Form 2


Function and Biology Details

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenylate cyclase Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 28.61 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21
  • Canonical: P9WQ35 (Residues: 212-443; Coverage: 52%)
Gene names: MTCY01B2.17c, Rv1625c, cya
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Nucleotide cyclase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P65
Unit cell:
a: 75.57Å b: 75.57Å c: 133.17Å
α: 90° β: 90° γ: 120°
R R work R free
0.199 0.196 0.26
Expression system: Escherichia coli BL21