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Structure of HOIP PUB domain bound to OTULIN PIM

Source organism: Homo sapiens
Biochemical function: ubiquitin-protein transferase activity
Biological process: not assigned
Cellular component: LUBAC complex

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EC 2.3.2.31: RBR-type E3 ubiquitin transferase

Reaction catalysed:
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Systematic name:
S-ubiquitinyl-[ubiquitin-conjugating E2 enzyme]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)

EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF09409
Domain description: PUB domain
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31
The deposited structure of PDB entry 4oyk contains 2 copies of Pfam domain PF09409 (PUB domain) in E3 ubiquitin-protein ligase RNF31. Showing 1 copy in chain A.

PF18486
Domain description: PNGase/UBA- or UBX-containing domain
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31
The deposited structure of PDB entry 4oyk contains 2 copies of Pfam domain PF18486 (PNGase/UBA- or UBX-containing domain) in E3 ubiquitin-protein ligase RNF31. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018997
Domain description: PUB domain
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31
IPR036339
Domain description: PUB-like domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31
IPR026254
Domain description: E3 ubiquitin-protein ligase RNF31-like
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31
IPR040641
Domain description: E3 ubiquitin-protein ligase RNF31, PUB domain
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31

Structure domain

CATH CATH domain
1.20.58.2190
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Occurring in:
  1. E3 ubiquitin-protein ligase RNF31
The deposited structure of PDB entry 4oyk contains 2 copies of CATH domain 1.20.58.2190 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in E3 ubiquitin-protein ligase RNF31. Showing 1 copy in chain A.

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