4ov6

X-ray diffraction
2.69Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chains: A, D
Molecule details ›
Chains: A, D
Length: 93 amino acids
Theoretical weight: 10.59 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8NBP7 (Residues: 60-152; Coverage: 14%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chains: B, E
Molecule details ›
Chains: B, E
Length: 294 amino acids
Theoretical weight: 31.3 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-446; Coverage: 44%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Subtilase family
Structure domains: Peptidase S8/S53 domain
Fibronectin type-III domain-containing protein Chains: F, G
Molecule details ›
Chains: F, G
Length: 99 amino acids
Theoretical weight: 10.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A075B5G3 (Residues: 1-99; Coverage: 100%)
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 75.2Å b: 118.6Å c: 168.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.231
Expression systems:
  • Trichoplusia ni
  • Escherichia coli BL21(DE3)