X-ray diffraction
3.35Å resolution

crystal structure of the C-terminal domain of p100/NF-kB2

Source organism: Homo sapiens
Primary publication:
p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.
Proc. Natl. Acad. Sci. U.S.A. 111 15946-51 (2014)
PMID: 25349408

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Nuclear factor NF-kappa-B p52 subunit Chain: A
Molecule details ›
Chain: A
Length: 359 amino acids
Theoretical weight: 38.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q00653 (Residues: 407-765; Coverage: 40%)
Gene names: LYT10, NFKB2
Sequence domains: Ankyrin repeat

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6322
Unit cell:
a: 196.67Å b: 196.67Å c: 68.46Å
α: 90° β: 90° γ: 120°
R R work R free
0.233 0.233 0.272
Expression system: Escherichia coli