X-ray diffraction
1.81Å resolution

Structure of a CYP105AS1 mutant in complex with compactin

Source organism: Amycolatopsis orientalis
Entry author: Leys D

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 monooxygenase CYP105AS1 Chain: A
Molecule details ›
Chain: A
Length: 457 amino acids
Theoretical weight: 50.63 KDa
Source organism: Amycolatopsis orientalis
Expression system: Escherichia coli
  • Canonical: W5VH56 (Residues: 1-401; Coverage: 100%)
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 39.36Å b: 86.81Å c: 139.63Å
α: 90° β: 90° γ: 90°
R R work R free
0.177 0.175 0.217
Expression system: Escherichia coli