› 4opa

X-ray diffraction
2.7Å resolution

X-ray structure of H6N6-NS1 delta(80-84) mutant

Released:
DOI: 10.2210/pdb4opa/pdb
PDB entry 4opa coloured by chain, front view.
PDB entry 4opa coloured by chain, side view.
PDB entry 4opa coloured by chain, top view.
Source organism: Influenza A virus (A/blue-winged teal/MN/993/1980(H6N6))
Primary publication:
The influenza A virus protein NS1 displays structural polymorphism.
Carrillo B, Choi JM, Bornholdt ZA, Sankaran B, Rice AP, Prasad BV
J Virol 88 4113-22 (2014)
PMID: 24478439

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 225 amino acids
Theoretical weight: 25.49 KDa
Source organism: Influenza A virus (A/blue-winged teal/MN/993/1980(H6N6))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q20NS3 (Residues: 1-230; Coverage: 98%)
Gene names: NS, NS1
Sequence domains: Influenza non-structural protein (NS1)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 43.87Å b: 120.85Å c: 53.26Å
α: 90° β: 103.42° γ: 90°
R-values:
R R work R free
0.2 0.2 0.25
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Influenza virus non-structural protein NS1: interferon antagonism and beyond.
Marc D. (2014)
7 more

8 mentions without citation

The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection.
Rosário-Ferreira et al. (2020)
7 more