PDBe 4oo9

X-ray diffraction
2.6Å resolution

Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant


Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Endolysin; Metabotropic glutamate receptor 5 Chain: A
Molecule details ›
Chain: A
Length: 444 amino acids
Theoretical weight: 49.92 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: P41594 (Residues: 569-678, 680-836; Coverage: 22%)
  • Canonical: P00720 (Residues: 2-162; Coverage: 98%)
Gene names: E, GPRC1E, GRM5, MGLUR5
Sequence domains:
Structure domains: Lysozyme

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 143.242Å b: 43.555Å c: 82.049Å
α: 90° β: 99.37° γ: 90°
R R work R free
0.241 0.239 0.275
Expression system: Spodoptera frugiperda