› 4on9

X-ray diffraction
2.71Å resolution

DECH box helicase domain

Released:
DOI: 10.2210/pdb4on9/pdb
PDB entry 4on9 coloured by chain, front view.
PDB entry 4on9 coloured by chain, side view.
PDB entry 4on9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal and solution structure of the human RIG-I SF2 domain.
Deimling T, Cui S, Lammens K, Hopfner KP, Witte G
Acta Crystallogr F Struct Biol Commun 70 1027-31 (2014)
PMID: 25084375

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-132018 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antiviral innate immune response receptor RIG-I Chains: A, B
Molecule details ›
Chains: A, B
Length: 580 amino acids
Theoretical weight: 66.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95786 (Residues: 230-793; Coverage: 61%)
Gene names: DDX58, RIGI
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 98.91Å b: 112.99Å c: 124.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.258
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Uchikawa et al. (2016)
1 more

3 mentions without citation

Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins.
Squeglia et al. (2020)
2 more