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Crystal structure of antibody VRC07 in complex with clade A/E 93TH057 HIV-1 gp120 core

X-ray diffraction
2.202Å resolution
PDB entry 4olu coloured by chain, front view.
PDB entry 4olu coloured by chain, side view.
PDB entry 4olu coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Envelope glycoprotein gp160 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 36242.94 Å2
Buried surface area: 8920.49 Å2
Dissociation area: 2,981.43 Å2
Dissociation energy (ΔGdiss): 6.23 kcal/mol
Dissociation entropy (TΔSdiss): 26.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-211977

Macromolecules

Envelope glycoprotein gp160
Chain: G
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-122, 201-303, 325-486; Coverage: 40%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
CATH: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
Envelope glycoprotein gp160 in PDB entry 4olu, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 4olu, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 4olu, assembly 1, top view.
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Antigen binding fragment of heavy chain: Antibody VRC01
Chain: H
Length: 228 amino acids
Theoretical weight: 24.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
Antigen binding fragment of heavy chain: Antibody VRC01 in PDB entry 4olu, assembly 1, front view.
Antigen binding fragment of heavy chain: Antibody VRC01 in PDB entry 4olu, assembly 1, side view.
Antigen binding fragment of heavy chain: Antibody VRC01 in PDB entry 4olu, assembly 1, top view.
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Antigen binding fragment of light chain: Antibody VRC01
Chain: L
Length: 210 amino acids
Theoretical weight: 23.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
Antigen binding fragment of light chain: Antibody VRC01 in PDB entry 4olu, assembly 1, front view.
Antigen binding fragment of light chain: Antibody VRC01 in PDB entry 4olu, assembly 1, side view.
Antigen binding fragment of light chain: Antibody VRC01 in PDB entry 4olu, assembly 1, top view.
Molecule details ›

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