Function and Biology

Crystal Structure of Human Argonaute2

Source organism: Homo sapiens
Biochemical function: mRNA binding
Biological process: translational initiation
Cellular component: mRNA cap binding complex

EC 3.1.26.n2: Argonaute-2

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester
Systematic name:
-
Alternative Name(s):
  • Argonaute RISC catalytic component 2
  • Eukaryotic translation initiation factor 2C 2

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08699
Domain description: Argonaute linker 1 domain
Occurring in:
  1. Protein argonaute-2
1 copy of Pfam domain PF08699 (Argonaute linker 1 domain) in Protein argonaute-2 in PDB 4ola.

PF02170
Domain description: PAZ domain
Occurring in:
  1. Protein argonaute-2
1 copy of Pfam domain PF02170 (PAZ domain) in Protein argonaute-2 in PDB 4ola.

PF02171
Domain description: Piwi domain
Occurring in:
  1. Protein argonaute-2
1 copy of Pfam domain PF02171 (Piwi domain) in Protein argonaute-2 in PDB 4ola.

PF16487
Domain description: Mid domain of argonaute
Occurring in:
  1. Protein argonaute-2
1 copy of Pfam domain PF16487 (Mid domain of argonaute) in Protein argonaute-2 in PDB 4ola.

PF16486
Domain description: N-terminal domain of argonaute
Occurring in:
  1. Protein argonaute-2
1 copy of Pfam domain PF16486 (N-terminal domain of argonaute) in Protein argonaute-2 in PDB 4ola.

PF16488
Domain description: Argonaute linker 2 domain
Occurring in:
  1. Protein argonaute-2
1 copy of Pfam domain PF16488 (Argonaute linker 2 domain) in Protein argonaute-2 in PDB 4ola.

InterPro InterPro annotations
IPR003100
Domain description: PAZ domain
Occurring in:
  1. Protein argonaute-2
IPR003165
Domain description: Piwi domain
Occurring in:
  1. Protein argonaute-2
IPR014811
Domain description: Argonaute, linker 1 domain
Occurring in:
  1. Protein argonaute-2
IPR036085
Domain description: PAZ domain superfamily
Occurring in:
  1. Protein argonaute-2
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Protein argonaute-2
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Protein argonaute-2
IPR032474
Domain description: Protein argonaute, N-terminal
Occurring in:
  1. Protein argonaute-2
IPR032473
Domain description: Protein argonaute, Mid domain
Occurring in:
  1. Protein argonaute-2
IPR032472
Domain description: Argonaute linker 2 domain
Occurring in:
  1. Protein argonaute-2

Structure domains

CATH CATH domains
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Protein argonaute-2
1 copy of CATH domain 3.40.50.2300 (Rossmann fold) in Protein argonaute-2 in PDB 4ola.
2.170.260.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: paz domain
Homology: paz domain
Occurring in:
  1. Protein argonaute-2
1 copy of CATH domain 2.170.260.10 (paz domain) in Protein argonaute-2 in PDB 4ola.
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Protein argonaute-2
1 copy of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Protein argonaute-2 in PDB 4ola.