Function and Biology

Crystal Structure of the human MST1-RASSF5 SARAH heterodimer

Source organism: Homo sapiens
Biochemical function: protein serine/threonine kinase activity
Biological process: signal transduction
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF16517
Domain description: Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
Occurring in:
  1. Ras association domain-containing protein 5
The deposited structure of PDB entry 4oh8 contains 1 copy of Pfam domain PF16517 (Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain) in Ras association domain-containing protein 5. Showing 1 copy in chain B.

PF11629
Domain description: C terminal SARAH domain of Mst1
Occurring in:
  1. Serine/threonine-protein kinase 4 18kDa subunit
The deposited structure of PDB entry 4oh8 contains 1 copy of Pfam domain PF11629 (C terminal SARAH domain of Mst1) in Serine/threonine-protein kinase 4 18kDa subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011524
IPR033614
Domain description: Ras association domain-containing protein 1-6
Occurring in:
  1. Ras association domain-containing protein 5
IPR024205
Domain description: Mst1/2 SARAH domain
Occurring in:
  1. Serine/threonine-protein kinase 4 18kDa subunit
IPR036674
Domain description: p53-like tetramerisation domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase 4 18kDa subunit

Structure domains

CATH CATH domains
1.20.5.110
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Ras association domain-containing protein 5
The deposited structure of PDB entry 4oh8 contains 1 copy of CATH domain 1.20.5.110 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Ras association domain-containing protein 5. Showing 1 copy in chain B.
4.10.170.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: p53, subunit A
Homology: p53-like tetramerisation domain
Occurring in:
  1. Serine/threonine-protein kinase 4 18kDa subunit
The deposited structure of PDB entry 4oh8 contains 1 copy of CATH domain 4.10.170.10 (p53, subunit A) in Serine/threonine-protein kinase 4 18kDa subunit. Showing 1 copy in chain A.