X-ray diffraction
1.95Å resolution

Structure of Human ALDH4A1 Crystallized in Space Group P21


Function and Biology Details

Reaction catalysed:
L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 549 amino acids
Theoretical weight: 60.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P30038 (Residues: 18-563; Coverage: 97%)
Gene names: ALDH4, ALDH4A1, P5CDH
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 91.96Å b: 121.335Å c: 93.397Å
α: 90° β: 104.23° γ: 90°
R R work R free
0.196 0.194 0.235
Expression system: Escherichia coli