› 4obu

X-ray diffraction
2.8Å resolution

Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (apo)

Released:
DOI: 10.2210/pdb4obu/pdb
PDB 4obu coloured by chain and viewed from the front.
PDB 4obu coloured by chain and viewed from the side.
PDB 4obu coloured by chain and viewed from the top.
Source organism: [Ruminococcus] gnavus ATCC 29149
Entry authors: Van Benschoten AH, Fraser JS

Function and Biology Details

Reaction catalysed: 
L-tryptophan = tryptamine + CO(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan decarboxylase Chains: A, B, C, E, F, G, H, U
Molecule details ›
Chains: A, B, C, E, F, G, H, U
Length: 490 amino acids
Theoretical weight: 55.02 KDa
Source organism: [Ruminococcus] gnavus ATCC 29149
Expression system: Escherichia coli
UniProt:
  • Canonical: A7B1V0 (Residues: 1-490; Coverage: 100%)
Gene name: RUMGNA_01526
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PLP 8 x PLP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P1
Unit cell:
a: 58.63Å b: 145.77Å c: 165.07Å
α: 72.85° β: 88.84° γ: 88.3°
R-values:
R R work R free
0.232 0.231 0.257
Expression system: Escherichia coli

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Citations

101 review citations

A Special Network Comprised of Macrophages, Epithelial Cells, and Gut Microbiota for Gut Homeostasis.
Chen et al. (2022)
100 more

5 mentions without citation

Current Advances on Structure-Function Relationships of Pyridoxal 5'-Phosphate-Dependent Enzymes.
Liang et al. (2019)
4 more