PDBe 4obs

X-ray diffraction
2.26Å resolution

Crystal structure of human alpha-L-iduronidase in the P212121 form

Released:
Source organism: Homo sapiens
Entry authors: Bie H, Yin J, He X, Kermode AR, James MNG

Function and Biology Details

Reaction catalysed:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-L-iduronidase Chain: A
Molecule details ›
Chain: A
Length: 627 amino acids
Theoretical weight: 70.05 KDa
Source organism: Homo sapiens
Expression system: Arabidopsis thaliana
UniProt:
  • Canonical: P35475 (Residues: 27-653; Coverage: 100%)
Gene name: IDUA
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P212121
Unit cell:
a: 72.64Å b: 78.03Å c: 112.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.235
Expression system: Arabidopsis thaliana