PDBe 4obr

X-ray diffraction
2.46Å resolution

Crystal structure of human alpha-L-iduronidase complex with alpha-L-iduronic acid

Released:
Source organism: Homo sapiens
Entry authors: Bie HY, Yin J, He X, Kermode AR, James MNG

Function and Biology Details

Reaction catalysed:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-L-iduronidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 627 amino acids
Theoretical weight: 70.05 KDa
Source organism: Homo sapiens
Expression system: Arabidopsis thaliana
UniProt:
  • Canonical: P35475 (Residues: 27-653; Coverage: 100%)
Gene name: IDUA
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: R3
Unit cell:
a: 258.94Å b: 258.94Å c: 71.53Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.239
Expression system: Arabidopsis thaliana