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Crystal structure of human ALKBH5 in complex with Mn2+

Source organism: Homo sapiens
Biochemical function: oxidative RNA demethylase activity
Biological process: obsolete oxidative single-stranded RNA demethylation
Cellular component: not assigned

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EC 1.14.11.53: mRNA N(6)-methyladenine demethylase

Reaction catalysed:
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2)
Systematic name:
mRNA-N(6)-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Alternative Name(s):
  • ALKBH5
  • FTO

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13532
Domain description: 2OG-Fe(II) oxygenase superfamily
Occurring in:
  1. RNA demethylase ALKBH5
The deposited structure of PDB entry 4o7x contains 1 copy of Pfam domain PF13532 (2OG-Fe(II) oxygenase superfamily) in RNA demethylase ALKBH5. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR032860
Domain description: RNA demethylase ALKBH5
Occurring in:
  1. RNA demethylase ALKBH5
IPR027450
Domain description: Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Occurring in:
  1. RNA demethylase ALKBH5
IPR037151
Domain description: Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Occurring in:
  1. RNA demethylase ALKBH5

Structure domain

CATH CATH domain
2.60.120.590
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Occurring in:
  1. RNA demethylase ALKBH5
The deposited structure of PDB entry 4o7x contains 1 copy of CATH domain 2.60.120.590 (Jelly Rolls) in RNA demethylase ALKBH5. Showing 1 copy in chain A.

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