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Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA

Source organism: Mus musculus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.7.86: Cyclic GMP-AMP synthase

Reaction catalysed:
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Systematic name:
ATP:GTP adenylyltransferase (cyclizing)
Alternative Name(s):
  • CGAMP synthase
  • CGAS

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF20266
Domain description: Mab-21 protein HhH/H2TH-like domain
Occurring in:
  1. Cyclic GMP-AMP synthase
The deposited structure of PDB entry 4o6a contains 2 copies of Pfam domain PF20266 (Mab-21 protein HhH/H2TH-like domain) in Cyclic GMP-AMP synthase. Showing 1 copy in chain A.

PF03281
Domain description: Mab-21 protein nucleotidyltransferase domain
Occurring in:
  1. Cyclic GMP-AMP synthase
The deposited structure of PDB entry 4o6a contains 2 copies of Pfam domain PF03281 (Mab-21 protein nucleotidyltransferase domain) in Cyclic GMP-AMP synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR046906
Domain description: Mab-21-like, HhH/H2TH-like domain
Occurring in:
  1. Cyclic GMP-AMP synthase
IPR046903
Domain description: Mab-21-like, nucleotidyltransferase domain
Occurring in:
  1. Cyclic GMP-AMP synthase
IPR024810
Domain description: MAB21L/Cyclic GMP-AMP synthase-like receptor
Occurring in:
  1. Cyclic GMP-AMP synthase

Structure domains

CATH CATH domains
1.10.1410.40
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Poly(a)-polymerase, middle domain
Homology: Poly(a)-polymerase, middle domain
Occurring in:
  1. Cyclic GMP-AMP synthase
The deposited structure of PDB entry 4o6a contains 2 copies of CATH domain 1.10.1410.40 (Poly(a)-polymerase, middle domain) in Cyclic GMP-AMP synthase. Showing 1 copy in chain A.
3.30.460.90
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 2
Homology: Beta Polymerase; domain 2
Occurring in:
  1. Cyclic GMP-AMP synthase
The deposited structure of PDB entry 4o6a contains 2 copies of CATH domain 3.30.460.90 (Beta Polymerase; domain 2) in Cyclic GMP-AMP synthase. Showing 1 copy in chain A.

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