4o68

X-ray diffraction
2.44Å resolution

Structure of human cyclic GMP-AMP synthase (cGAS)

Released:

Function and Biology Details

Reaction catalysed:
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic GMP-AMP synthase Chain: A
Molecule details ›
Chain: A
Length: 376 amino acids
Theoretical weight: 43.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N884 (Residues: 147-522; Coverage: 72%)
Gene names: C6orf150, CGAS, MB21D1
Sequence domains: Mab-21 protein
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 162.194Å b: 47.051Å c: 58.404Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.18 0.244
Expression system: Escherichia coli