4o15

X-ray diffraction
1.8Å resolution

The crystal structure of a mutant NAMPT (S165F) in complex with GNE-618

Released:
Source organism: Homo sapiens
Entry authors: Oh A, Coons M, Brillantes B, Wang W

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 501 amino acids
Theoretical weight: 57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43490 (Residues: 1-491; Coverage: 100%)
Gene names: NAMPT, PBEF, PBEF1
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 60.452Å b: 106.399Å c: 83.63Å
α: 90° β: 96.83° γ: 90°
R-values:
R R work R free
0.154 0.152 0.183
Expression system: Escherichia coli