X-ray diffraction
1.75Å resolution

The crystal structure of NAMPT in complex with GNE-618

Source organism: Homo sapiens
Entry authors: Oh A, Coons M, Brillantes B, Wang W

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Nicotinamide phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 501 amino acids
Theoretical weight: 56.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P43490 (Residues: 1-491; Coverage: 100%)
Gene names: NAMPT, PBEF, PBEF1
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 60.556Å b: 106.206Å c: 82.949Å
α: 90° β: 96.39° γ: 90°
R R work R free
0.198 0.197 0.227
Expression system: Escherichia coli