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Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange

Source organism: Homo sapiens
Biochemical function: GTP binding
Biological process: signal transduction
Cellular component: membrane

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. GTPase HRas, N-terminally processed
  2. GTPase HRas, N-terminally processed
The deposited structure of PDB entry 4nyi contains 1 copy of Pfam domain PF00071 (Ras family) in GTPase HRas, N-terminally processed. Showing 1 copy in chain A [auth Q].
The deposited structure of PDB entry 4nyi contains 1 copy of Pfam domain PF00071 (Ras family) in GTPase HRas, N-terminally processed. Showing 1 copy in chain B [auth R].

PF00617
Domain description: RasGEF domain
Occurring in:
  1. Son of sevenless homolog 1
The deposited structure of PDB entry 4nyi contains 1 copy of Pfam domain PF00617 (RasGEF domain) in Son of sevenless homolog 1. Showing 1 copy in chain C [auth S].

PF00618
Domain description: RasGEF N-terminal motif
Occurring in:
  1. Son of sevenless homolog 1
The deposited structure of PDB entry 4nyi contains 1 copy of Pfam domain PF00618 (RasGEF N-terminal motif) in Son of sevenless homolog 1. Showing 1 copy in chain C [auth S].

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. GTPase HRas, N-terminally processed
  2. GTPase HRas, N-terminally processed
IPR001895
Domain description: Ras guanine-nucleotide exchange factors catalytic domain
Occurring in:
  1. Son of sevenless homolog 1
IPR000651
Domain description: Ras-like guanine nucleotide exchange factor, N-terminal
Occurring in:
  1. Son of sevenless homolog 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. GTPase HRas, N-terminally processed
  2. GTPase HRas, N-terminally processed
IPR020849
Domain description: Small GTPase, Ras-type
Occurring in:
  1. GTPase HRas, N-terminally processed
  2. GTPase HRas, N-terminally processed
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. GTPase HRas, N-terminally processed
  2. GTPase HRas, N-terminally processed
IPR019804
Domain description: Ras guanine-nucleotide exchange factor, conserved site
Occurring in:
  1. Son of sevenless homolog 1
IPR036964
Domain description: Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Occurring in:
  1. Son of sevenless homolog 1
IPR008937
Domain description: Ras-like guanine nucleotide exchange factor
Occurring in:
  1. Son of sevenless homolog 1
IPR023578
Domain description: Ras guanine nucleotide exchange factor domain superfamily
Occurring in:
  1. Son of sevenless homolog 1

Structure domains

CATH CATH domains
1.10.840.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Son of Sevenless (SoS) protein; Chain S, domain 2
Homology: Ras guanine-nucleotide exchange factors catalytic domain
Occurring in:
  1. Son of sevenless homolog 1
The deposited structure of PDB entry 4nyi contains 1 copy of CATH domain 1.10.840.10 (Son of Sevenless (SoS) protein; Chain S, domain 2) in Son of sevenless homolog 1. Showing 1 copy in chain C [auth S].
1.20.870.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Son of sevenless (SoS) protein; Chain S, domain 1
Homology: Son of sevenless (SoS) protein Chain: S domain 1
Occurring in:
  1. Son of sevenless homolog 1
The deposited structure of PDB entry 4nyi contains 1 copy of CATH domain 1.20.870.10 (Son of sevenless (SoS) protein; Chain S, domain 1) in Son of sevenless homolog 1. Showing 1 copy in chain C [auth S].
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. GTPase HRas, N-terminally processed
  2. GTPase HRas, N-terminally processed
The deposited structure of PDB entry 4nyi contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in GTPase HRas, N-terminally processed. Showing 1 copy in chain A [auth Q].
The deposited structure of PDB entry 4nyi contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in GTPase HRas, N-terminally processed. Showing 1 copy in chain B [auth R].

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