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Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5

Source organism: Mus musculus
Biochemical function: peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.34: Legumain

Reaction catalysed:
Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.
Systematic name:
-
Alternative Name(s):
  • Asparaginyl endopeptidase
  • Bean endopeptidase
  • Citvac
  • Hemoglobinase
  • PRSC1 gene product (Homo sapiens)
  • Phaseolin
  • Proteinase B
  • Vicilin peptidohydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01650
Domain description: Peptidase C13 family
Occurring in:
  1. Legumain
The deposited structure of PDB entry 4noj contains 1 copy of Pfam domain PF01650 (Peptidase C13 family) in Legumain. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR001096
Domain description: Peptidase C13, legumain
Occurring in:
  1. Legumain

Structure domain

CATH CATH domain
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Legumain
The deposited structure of PDB entry 4noj contains 1 copy of CATH domain 3.40.50.1460 (Rossmann fold) in Legumain. Showing 1 copy in chain A.

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