4nog

X-ray diffraction
1.2Å resolution

Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate

Released:
Source organism: Toxoplasma gondii ME49
Entry authors: Filippova EV, Halavaty A, Ruan J, Shuvalova L, Flores K, Dubrovska I, Ngo H, Shanmugam D, Roos D, Anderson WF, Center for Structural Genomics of Infectious Diseases, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ornithine aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 442 amino acids
Theoretical weight: 49.03 KDa
Source organism: Toxoplasma gondii ME49
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: S8EY38 (Residues: 17-441; Coverage: 96%)
Gene name: TGME49_269110
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 56.19Å b: 61.328Å c: 63.678Å
α: 100.58° β: 93.23° γ: 107.74°
R-values:
R R work R free
0.135 0.133 0.165
Expression system: Escherichia coli BL21(DE3)